Synthesis and bioactivity of fluorescence- and biotin-labeled lipid a analogues for investigation of recognition mechanism in innate immunity

Yukari Fujimoto, Eiji Kimura, Shuichi Murata, Shoichi Kusumoto, Koichi Fukase

研究成果: Article査読

8 被引用数 (Scopus)

抄録

Fluorescence- and biotin-labeled lipid A analogues were synthesized for the investigation of bacterial lipopolysaccharide (LPS)/lipid A recognition in the innate immune system. For the introduction of the labeling moiety, a hydrophilic glutaryl-glucose linker was used for maintaining the bioactivity and also for preventing self-aggregation, which causes quenching of the fluorescence. We also observed the biological activity of the labeled compounds.

本文言語English
ページ(範囲)539-543
ページ数5
ジャーナルTetrahedron Letters
47
4
DOI
出版ステータスPublished - 2006 1 23
外部発表はい

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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