抄録
Fluorescence- and biotin-labeled lipid A analogues were synthesized for the investigation of bacterial lipopolysaccharide (LPS)/lipid A recognition in the innate immune system. For the introduction of the labeling moiety, a hydrophilic glutaryl-glucose linker was used for maintaining the bioactivity and also for preventing self-aggregation, which causes quenching of the fluorescence. We also observed the biological activity of the labeled compounds.
本文言語 | English |
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ページ(範囲) | 539-543 |
ページ数 | 5 |
ジャーナル | Tetrahedron Letters |
巻 | 47 |
号 | 4 |
DOI | |
出版ステータス | Published - 2006 1 23 |
外部発表 | はい |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry