@article{817012ac920148d293b627e4e63fbd51,
title = "Synthesis and bioactivity of fluorescence- and biotin-labeled lipid a analogues for investigation of recognition mechanism in innate immunity",
abstract = "Fluorescence- and biotin-labeled lipid A analogues were synthesized for the investigation of bacterial lipopolysaccharide (LPS)/lipid A recognition in the innate immune system. For the introduction of the labeling moiety, a hydrophilic glutaryl-glucose linker was used for maintaining the bioactivity and also for preventing self-aggregation, which causes quenching of the fluorescence. We also observed the biological activity of the labeled compounds.",
keywords = "Biotin-label, Fluorescence-label, Immunostimulation, Innate immunity, Lipid A",
author = "Yukari Fujimoto and Eiji Kimura and Shuichi Murata and Shoichi Kusumoto and Koichi Fukase",
note = "Funding Information: This work was supported in part by Grants-in Aid for Scientific Research (Nos. 17035050, 17310128, 17510178, and 13NP0401) from MEXT and JSPS, and Hayashi Memorial Foundation for Female Natural Scientists (to Y.F.).",
year = "2006",
month = jan,
day = "23",
doi = "10.1016/j.tetlet.2005.11.041",
language = "English",
volume = "47",
pages = "539--543",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "4",
}