Synthesis and biological activity of ester and ether analogues of α-galactosylceramide (KRN7000)

Masao Shiozaki, Takuya Tashiro, Hiroyuki Koshino, Ryusuke Nakagawa, Sayo Inoue, Tomokuni Shigeura, Hiroshi Watarai, Masaru Taniguchi, Kenji Mori

研究成果: Article

34 引用 (Scopus)

抜粋

These three ester analogues showed activity for IFNγ, and IL-4 production of iNKT cells. α-Galactosylceramide (αGalCer, KRN7000) has been identified as a modulator of immunological processes through its capacity to bind iNKT cells mediated by CD1d molecules. Some analogues in while the amide group in αGalCer is replaced with ester or ether groups were synthesized from d-arabinitol or l-ribose to evaluate their ability to activate iNKT cells. Ester analogues 30a, 31a, and 61 showed activity for IFNγ and IL-4 production of iNKT cells, while ether (31b) and 4-methoxy ester (76) analogues of α-galactosylceramide were not active for iNKT cells.

元の言語English
ページ(範囲)1663-1684
ページ数22
ジャーナルCarbohydrate Research
345
発行部数12
DOI
出版物ステータスPublished - 2010 8 16

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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  • これを引用

    Shiozaki, M., Tashiro, T., Koshino, H., Nakagawa, R., Inoue, S., Shigeura, T., Watarai, H., Taniguchi, M., & Mori, K. (2010). Synthesis and biological activity of ester and ether analogues of α-galactosylceramide (KRN7000). Carbohydrate Research, 345(12), 1663-1684. https://doi.org/10.1016/j.carres.2010.05.003