Synthesis and biological evaluation of a MraY selective analogue of tunicamycins

Kazuki Yamamoto, Toyotaka Sato, Yuta Hikiji, Akira Katsuyama, Takanori Matsumaru, Fumika Yakushiji, Shin Ichi Yokota, Satoshi Ichikawa

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Tunicamycins, which are nucleoside natural products, inhibit both bacterial phospho-N-acetylmuraminic acid (MurNAc)-pentapeptide translocase (MraY) and human UDP-N-acetylglucosamine (GlcNAc): polyprenol phosphate translocase (GPT). The improved synthesis and detailed biological evaluation of an MraY-selective inhibitor, 2, where the GlcNAc moiety was modified to a MurNAc amide, has been described.

本文言語English
ページ(範囲)349-364
ページ数16
ジャーナルNucleosides, Nucleotides and Nucleic Acids
39
1-3
DOI
出版ステータスPublished - 2020 2 20

ASJC Scopus subject areas

  • 生化学
  • 分子医療
  • 遺伝学

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