Synthesis and biological evaluation of the natural product komaroviquinone and related compounds aiming at a potential therapeutic lead compound for high-risk multiple myeloma

Yutaka Suto, Mariko Sato, Kota Fujimori, Shotaro Kitabatake, Mikio Okayama, Daiju Ichikawa, Maiko Matsushita, Noriyuki Yamagiwa, Genji Iwasaki, Fumiyuki Kiuchi, Yutaka Hattori

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Alternatives of treatments for multiple myeloma (MM) have become increasingly available with the advent of new drugs such as proteasome inhibitors, thalidomide derivatives, histone deacetylase inhibitors, and antibody drugs. However, high-risk MM cases that are refractory to novel drugs remain, and further optimization of chemotherapeutics is urgently needed. We had achieved asymmetric total synthesis of komaroviquinone, which is a natural product from the plant Dracocephalum komarovi. Similar to several leading antitumor agents that have been developed from natural compounds, we describe the antitumor activity and cytotoxicity of komaroviquinone and related compounds in bone marrow cells. Our data suggested that komaroviquinone-related agents have potential as starting compounds for anticancer drug development.

本文言語English
ページ(範囲)4558-4563
ページ数6
ジャーナルBioorganic and Medicinal Chemistry Letters
27
19
DOI
出版ステータスPublished - 2017

ASJC Scopus subject areas

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬科学
  • 創薬
  • 臨床生化学
  • 有機化学

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