Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB

Yuichi Ishikawa; Miyuki Tachibana; Chino Matsui; Rika Obata; Kazuo Umezawa; Shigeru Nishiyama

doi:10.1016/j.bmcl.2009.01.107

Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB

Yuichi Ishikawa, Miyuki Tachibana, Chino Matsui, Rika Obata, Kazuo Umezawa, Shigeru Nishiyama

人文社会学科

研究成果: Article › 査読

25 被引用数 (Scopus)

抄録

Synthesis of 9-methylstreptimidone analogs and their inhibitory activities against NF-κB (nuclear factor-κB) are reported. Among several active derivatives synthesized in this study, 8 with a relatively simple structure, exhibited inhibitory activity against LPS-induced NO production comparable to that of 9-methylstreptimidone.

本文言語	English
ページ（範囲）	1726-1728
ページ数	3
ジャーナル	Bioorganic and Medicinal Chemistry Letters
巻	19
号	6
DOI	https://doi.org/10.1016/j.bmcl.2009.01.107
出版ステータス	Published - 2009 3 15

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

文献へのアクセス

10.1016/j.bmcl.2009.01.107

フィンガープリント「Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

@article{33ff16ced79948c7bd1edf61f47042cb,

title = "Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB",

abstract = "Synthesis of 9-methylstreptimidone analogs and their inhibitory activities against NF-κB (nuclear factor-κB) are reported. Among several active derivatives synthesized in this study, 8 with a relatively simple structure, exhibited inhibitory activity against LPS-induced NO production comparable to that of 9-methylstreptimidone.",

keywords = "9-Methylstreptimidone, Inhibitor, NF-κB",

author = "Yuichi Ishikawa and Miyuki Tachibana and Chino Matsui and Rika Obata and Kazuo Umezawa and Shigeru Nishiyama",

year = "2009",

month = mar,

day = "15",

doi = "10.1016/j.bmcl.2009.01.107",

language = "English",

volume = "19",

pages = "1726--1728",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "6",

}

TY - JOUR

T1 - Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB

AU - Ishikawa, Yuichi

AU - Tachibana, Miyuki

AU - Matsui, Chino

AU - Obata, Rika

AU - Umezawa, Kazuo

AU - Nishiyama, Shigeru

PY - 2009/3/15

Y1 - 2009/3/15

N2 - Synthesis of 9-methylstreptimidone analogs and their inhibitory activities against NF-κB (nuclear factor-κB) are reported. Among several active derivatives synthesized in this study, 8 with a relatively simple structure, exhibited inhibitory activity against LPS-induced NO production comparable to that of 9-methylstreptimidone.

AB - Synthesis of 9-methylstreptimidone analogs and their inhibitory activities against NF-κB (nuclear factor-κB) are reported. Among several active derivatives synthesized in this study, 8 with a relatively simple structure, exhibited inhibitory activity against LPS-induced NO production comparable to that of 9-methylstreptimidone.

KW - 9-Methylstreptimidone

KW - Inhibitor

KW - NF-κB

UR - http://www.scopus.com/inward/record.url?scp=61349093025&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=61349093025&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2009.01.107

DO - 10.1016/j.bmcl.2009.01.107

M3 - Article

C2 - 19231181

AN - SCOPUS:61349093025

VL - 19

SP - 1726

EP - 1728

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 6

ER -