Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB

Yuichi Ishikawa, Miyuki Tachibana, Chino Matsui, Rika Obata, Kazuo Umezawa, Shigeru Nishiyama

研究成果: Article査読

25 被引用数 (Scopus)

抄録

Synthesis of 9-methylstreptimidone analogs and their inhibitory activities against NF-κB (nuclear factor-κB) are reported. Among several active derivatives synthesized in this study, 8 with a relatively simple structure, exhibited inhibitory activity against LPS-induced NO production comparable to that of 9-methylstreptimidone.

本文言語English
ページ(範囲)1726-1728
ページ数3
ジャーナルBioorganic and Medicinal Chemistry Letters
19
6
DOI
出版ステータスPublished - 2009 3 15

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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