Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB

Yuichi Ishikawa; Miyuki Tachibana; Chino Matsui; Rika Obata; Kazuo Umezawa; Shigeru Nishiyama

doi:10.1016/j.bmcl.2009.01.107

Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB

Yuichi Ishikawa, Miyuki Tachibana, Chino Matsui, Rika Obata, Kazuo Umezawa, Shigeru Nishiyama

人文社会学科

研究成果: Article › 査読

25 被引用数 (Scopus)

抄録

Synthesis of 9-methylstreptimidone analogs and their inhibitory activities against NF-κB (nuclear factor-κB) are reported. Among several active derivatives synthesized in this study, 8 with a relatively simple structure, exhibited inhibitory activity against LPS-induced NO production comparable to that of 9-methylstreptimidone.

本文言語	English
ページ（範囲）	1726-1728
ページ数	3
ジャーナル	Bioorganic and Medicinal Chemistry Letters
巻	19
号	6
DOI	https://doi.org/10.1016/j.bmcl.2009.01.107
出版ステータス	Published - 2009 3 15

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

文献へのアクセス

10.1016/j.bmcl.2009.01.107

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引用スタイル

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abstract = "Synthesis of 9-methylstreptimidone analogs and their inhibitory activities against NF-κB (nuclear factor-κB) are reported. Among several active derivatives synthesized in this study, 8 with a relatively simple structure, exhibited inhibitory activity against LPS-induced NO production comparable to that of 9-methylstreptimidone.",

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note = "Funding Information: This work was supported by High-Tech Research Center Project for Private Universities: matching fund subsidy from MEXT, 2006–2011. ",

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AU - Tachibana, Miyuki

AU - Matsui, Chino

AU - Obata, Rika

AU - Umezawa, Kazuo

AU - Nishiyama, Shigeru

N1 - Funding Information: This work was supported by High-Tech Research Center Project for Private Universities: matching fund subsidy from MEXT, 2006–2011.

PY - 2009/3/15

Y1 - 2009/3/15

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KW - 9-Methylstreptimidone

KW - Inhibitor

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