Synthesis and biological properties of tensyuic acids B, C, and E, and investigation of the optical purity of natural tensyuic acid B

Takanori Matsumaru, Toshiaki Sunazuka, Tomoyasu Hirose, Aki Ishiyama, Miyuki Namatame, Takashi Fukuda, Hiroshi Tomoda, Kazuhiko Otoguro, Satoshi Omura

研究成果: Article査読

7 被引用数 (Scopus)

抄録

The first, concise total synthesis of (±)-tensyuic acids B, C, and E, using chemoselective formal SN2′ type Grignard reactions and selective esterification, is described. In addition, the optical purity of natural (±)-tensyuic acid B was determined using Chirabite-AR. Synthetic tensyuic acids, together with their intermediate compounds, were found to possess useful bioactive properties, with some of them showing potent activity against Trypanosoma brucei brucei strain GUTat 3.1.

本文言語English
ページ(範囲)7369-7377
ページ数9
ジャーナルTetrahedron
64
30-31
DOI
出版ステータスPublished - 2008 7 21
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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