抄録
We describe the first total synthesis and structural determination of akaterpin, an inhibitor of phosphatidylinositol-specific phospholipase C (PI-PLC). The key features of the synthetic strategy include a regio- and stereoselective C-alkylation at the angular C1′ position and an exo-selective intermolecular Diels-Alder reaction. The relative stereochemistry was determined by a comparison of the NMR spectra of synthetic akaterpin with those of natural akaterpin.
本文言語 | English |
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ページ(範囲) | 4961-4964 |
ページ数 | 4 |
ジャーナル | Tetrahedron Letters |
巻 | 52 |
号 | 38 |
DOI | |
出版ステータス | Published - 2011 9 21 |
外部発表 | はい |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry