Synthesis and innate immunosuppressive effect of 1,2-cyclopentanediol derivatives

Haruhisa Kikuchi, Kaori Okazaki, Mizuki Sekiya, Yasuyuki Uryu, Kazunori Ueda, Yasuhiro Katou, Shoichiro Kurata, Yoshiteru Oshima

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Innate immunity is the front line of self-defense against infectious microorganisms. In mammals, innate immunity interacts with adaptive immunity and plays a key role in regulating the immune response. Therefore, innate immunity is a good pharmaceutical target for the development of immune regulators. After searching for natural substances that regulate innate immunity using an ex vivo Drosophila culture system, we identified a cyclopentanediol-type compound 1 as an immunosuppressor. In this study, we synthesized and evaluated 1 and its derivatives. Several methylamide- or phenylamide-containing derivatives showed effects that were 20-25 times more potent than those of 1.

本文言語English
ページ(範囲)1263-1273
ページ数11
ジャーナルEuropean Journal of Medicinal Chemistry
46
4
DOI
出版ステータスPublished - 2011 4
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 創薬
  • 有機化学

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