@article{a9efac202754424faf1f12cda239878b,
title = "Synthesis and luminescence properties of biphenyl-type firefly luciferin analogs with a new, near-infrared light-emitting bioluminophore",
abstract = "New firefly luciferin analogs of the 4,4′-substituted biphenyl-type were synthesized. One analog with a 4′-dimethylamino group possessed bioluminescence activity, emitting near-infrared biological window light at 675 nm suitable for deep-site bioimaging of living animals. The chemiluminescence light-emission maximum of the corresponding methyl ester of the bioluminescence active analog was 500 nm, implying that biphenyl and thiazolinone rings in the light emitter might be placed in a coplanar conformation at the polar luciferase active site.",
keywords = "Biological window, Bioluminescence, Biphenyl-type, Chemiluminescence, Firefly luciferin analog, Near-infrared",
author = "Chihiro Miura and Masahiro Kiyama and Satoshi Iwano and Kazuto Ito and Rika Obata and Takashi Hirano and Shojiro Maki and Haruki Niwa",
note = "Funding Information: This work was supported by Grants-in-Aid for Exploratory Research ( No. 24650633 ) to S.M. from the Ministry of Education, Culture, Sports, Science and Technology , and Adaptable & Seamless Technology Transfer Program through Target-driven R&D (A-Step) (No. AS2321366E ) to S.M. from the Japan Science and Technology Agency . ",
year = "2013",
month = nov,
day = "18",
doi = "10.1016/j.tet.2013.09.018",
language = "English",
volume = "69",
pages = "9726--9734",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Limited",
number = "46",
}