Synthesis and luminescence properties of biphenyl-type firefly luciferin analogs with a new, near-infrared light-emitting bioluminophore

Chihiro Miura, Masahiro Kiyama, Satoshi Iwano, Kazuto Ito, Rika Obata, Takashi Hirano, Shojiro Maki, Haruki Niwa

研究成果: Article査読

32 被引用数 (Scopus)

抄録

New firefly luciferin analogs of the 4,4′-substituted biphenyl-type were synthesized. One analog with a 4′-dimethylamino group possessed bioluminescence activity, emitting near-infrared biological window light at 675 nm suitable for deep-site bioimaging of living animals. The chemiluminescence light-emission maximum of the corresponding methyl ester of the bioluminescence active analog was 500 nm, implying that biphenyl and thiazolinone rings in the light emitter might be placed in a coplanar conformation at the polar luciferase active site.

本文言語English
ページ(範囲)9726-9734
ページ数9
ジャーナルTetrahedron
69
46
DOI
出版ステータスPublished - 2013 11 18

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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