Synthesis and structure - Activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors

Seigo Ishibuchi, Hiroshi Morimoto, Takanori Oe, Tsuguo Ikebe, Hiroyoshi Inoue, Atsushi Fukunari, Miho Kamezawa, Ichimaro Yamada, Yoichi Naka

研究成果: Article査読

102 被引用数 (Scopus)

抄録

A series of 1-phenylpyrazoles was evaluated for inhibitory activity against xanthine oxidase in vitro. Of the compounds prepared, 1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid (Y-700) had the most potent enzyme inhibition and displayed longer-lasting hypouricemic action than did allopurinol in a rat model of hyperuricemia induced by the uricase inhibitor potassium oxonate.

本文言語English
ページ(範囲)879-882
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
11
7
DOI
出版ステータスPublished - 2001 4 9
外部発表はい

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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