Synthesis of 25-hydroxy-19-norvitamin D3 analogs and their antiproliferative activities on prostate cells

Midori A. Arai, Ryuji Tsutsumi, Hideki Hara, Tai C. Chen, Toshiyuki Sakaki, Naoko Urushino, Kuniyo Inouye, Atsushi Kittaka

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Synthesis of 25-hydroxy-19-norvitamin D3 derivatives as prohormone type agents for anti-prostate diseases was accomplished utilizing Julia-type olefination. Synthesized compounds showed potent antiproliferative activity on an immortalized normal prostate cell line, PZ-HPV-7, which has high 1α-hydroxylase activity. Furthermore, we demonstrated that 25-hydroxy-19-norvitamin D3 was hydroxylated at the 1α position to form 1α,25-dihydroxy-19-norvitamin D3 by a recombinant human 1α-hydroxylase (CYP27B1) in a cell-free system.

本文言語English
ページ(範囲)469-479
ページ数11
ジャーナルHeterocycles
66
1
DOI
出版ステータスPublished - 2005 12月 31
外部発表はい

ASJC Scopus subject areas

  • 分析化学
  • 薬理学
  • 有機化学

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