Synthesis of a novel class of cdc25A inhibitors from Vitamin D3

Kosuke Dodo, Masato Takahashi, Yuji Yamada, Yoshikazu Sugimoto, Yuichi Hashimoto, Ryuichi Shirai

研究成果: Article査読

21 被引用数 (Scopus)

抄録

We have developed a novel class of cdc25A inhibitors by drastic modification of hydrophobic and hydrophillic substructures of dysidiolide. The unsaturated derivative 3b strongly inhibited cdc25A (IC50=7.7 μM) and caused G1 arrest of HL60 cells. (C) 2000 Elsevier Science Ltd. All rights reserved.

本文言語English
ページ(範囲)615-617
ページ数3
ジャーナルBioorganic and Medicinal Chemistry Letters
10
7
DOI
出版ステータスPublished - 2000 4 3

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

フィンガープリント 「Synthesis of a novel class of cdc25A inhibitors from Vitamin D<sub>3</sub>」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル