Synthesis of a potential key intermediate of akaterpin, specific inhibitor of PI-PLC

Nobuyuki Kawai, Yuko Fujibayashi, Seiya Kuwabara, Ken Ichi Takao, Yasuharu Ijuin, Susumu Kobayashi

研究成果: Article査読

30 被引用数 (Scopus)

抄録

In order to establish the stereochemistry of akaterpin, a specific inhibitor of PI-PLC, cis-decalin 2 and trans-decalin 3 were prepared. Comparison of NMR spectra of 2 and 3 with those of akaterpin indicated that the upper decalin has a cis-fused structure. Based on the methodology developed here, synthesis of a potential intermediate 32 for the total synthesis of akaterpin was successfully achieved. Further, resolution of β,γ-unsaturated ketone 6 was accomplished using chiral sulfoxyimine. (C) 2000 Elsevier Science Ltd.

本文言語English
ページ(範囲)6467-6478
ページ数12
ジャーナルTetrahedron
56
35
DOI
出版ステータスPublished - 2000 8月 25

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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