Synthesis of (+)- and (-)-nojirimycin and their 1-deoxyderivatives from myo-inositol

Noritaka Chida, Yuka Furuno, Hiroyuki Ikemoto, Seiichiro Ogawa

研究成果: Article査読

30 被引用数 (Scopus)

抄録

The conversion of the naturally abundant cyclitol, myo-inositol (4), into (+)-nojirimycin (la), its enantiomer (1b), and their 1-deoxy analogues (2a and 2b) is described. Biological assay of 2a, 2b, and the bisulfite adducts of 1a and 1b (3a and 3b) showed that the compounds having the unnatural l-gluco configuration (2b and 3b) possess moderate-to-high inhibitory activity against almond β-d-glucosidase and bovine liver β-d-galactosidase.

本文言語English
ページ(範囲)185-194
ページ数10
ジャーナルCarbohydrate Research
237
C
DOI
出版ステータスPublished - 1992 12月 31

ASJC Scopus subject areas

  • 分析化学
  • 生化学
  • 有機化学

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