Synthesis of (+)- and (-)-nojirimycin and their 1-deoxyderivatives from myo-inositol

Noritaka Chida, Yuka Furuno, Hiroyuki Ikemoto, Seiichiro Ogawa

研究成果: Article

30 引用 (Scopus)

抜粋

The conversion of the naturally abundant cyclitol, myo-inositol (4), into (+)-nojirimycin (la), its enantiomer (1b), and their 1-deoxy analogues (2a and 2b) is described. Biological assay of 2a, 2b, and the bisulfite adducts of 1a and 1b (3a and 3b) showed that the compounds having the unnatural l-gluco configuration (2b and 3b) possess moderate-to-high inhibitory activity against almond β-d-glucosidase and bovine liver β-d-galactosidase.

元の言語English
ページ(範囲)185-194
ページ数10
ジャーナルCarbohydrate Research
237
発行部数C
DOI
出版物ステータスPublished - 1992 12 31

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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