Synthesis of bacterial glycoconjugates and their bio-functional studies in innate immunity

Koichi Fukase, Yukari Fujimoto, Atsushi Shimoyama, Katsunori Tanaka

研究成果: Review article査読

3 被引用数 (Scopus)

抄録

Immunostimulating glycoconjugates from bacteria were synthesized for elucidation of the recognition with innate immune receptors. Synthesis of partial structures and analogues of lipopolysaccharide and its bioactive principle 'lipid A' contributed the elucidation of mode of action, i.e., interaction of lipopolysaccharide with its receptor 'TLR4/MD-2 complex'. Immunomodulation by parasitic bacteria -Helicobacter pylori' was elucidated by using synthetic lipopolysaccharide partial structures. Intracellular peptidoglycan receptors, 'Nod1' and 'Nod2', and their ligand structures were identified by using synthetic peptidoglycan partial structures. New Nod1 ligands were identified from the bacterial supernatant. In vivo function of Nod1 was studied by using synthetic ligands found from small library of Nod1 ligands.

本文言語English
ページ(範囲)113-130
ページ数18
ジャーナルYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
70
2
DOI
出版ステータスPublished - 2012
外部発表はい

ASJC Scopus subject areas

  • Organic Chemistry

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