Synthesis of chiloscyphones and the biological activities of their synthetic intermediates against methicillin-resistant Staphylococcus aureus (MRSA)

Junichi Shiina, Rika Obata, Hiroshi Tomoda, Shigeru Nishiyama

研究成果: Article

5 引用 (Scopus)

抄録

The total syntheses of chiloscyphone (1) and isochiloscyphone (2) have been achieved. Furthermore, the synthetic intermediate 5 shows biological activity against methicillin-resistant Staphyrococcus aureus, and compounds 5, 17, and 18, display imipenem-type activity. The tricyclic lactone framework, which includes an α,β-unsaturated ketone moiety, might play a crucial role in the anti-MRSA activity.

元の言語English
ページ(範囲)2362-2370
ページ数9
ジャーナルEuropean Journal of Organic Chemistry
発行部数10
DOI
出版物ステータスPublished - 2006 5 12

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Methicillin
staphylococcus
activity (biology)
Bioactivity
Imipenem
Lactones
synthesis
Ketones
ketones

ASJC Scopus subject areas

  • Organic Chemistry

これを引用

Synthesis of chiloscyphones and the biological activities of their synthetic intermediates against methicillin-resistant Staphylococcus aureus (MRSA). / Shiina, Junichi; Obata, Rika; Tomoda, Hiroshi; Nishiyama, Shigeru.

:: European Journal of Organic Chemistry, 番号 10, 12.05.2006, p. 2362-2370.

研究成果: Article

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