Synthesis of chiloscyphones and the biological activities of their synthetic intermediates against methicillin-resistant Staphylococcus aureus (MRSA)

Junichi Shiina, Rika Obata, Hiroshi Tomoda, Shigeru Nishiyama

研究成果: Article査読

6 被引用数 (Scopus)

抄録

The total syntheses of chiloscyphone (1) and isochiloscyphone (2) have been achieved. Furthermore, the synthetic intermediate 5 shows biological activity against methicillin-resistant Staphyrococcus aureus, and compounds 5, 17, and 18, display imipenem-type activity. The tricyclic lactone framework, which includes an α,β-unsaturated ketone moiety, might play a crucial role in the anti-MRSA activity.

本文言語English
ページ(範囲)2362-2370
ページ数9
ジャーナルEuropean Journal of Organic Chemistry
10
DOI
出版ステータスPublished - 2006 5月 12

ASJC Scopus subject areas

  • 物理化学および理論化学
  • 有機化学

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