Synthesis of gerfelin and related analogous compounds

Md Sadequl Islam, Mitsuhiro Kitagawa, Masaya Imoto, Takeshi Kitahara, Hidenori Watanabe

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Gerfelin, an inhibitor of human geranylgeranyl diphosphate (GGPP) synthase that has been isolated from a culture broth of Beauveria felina QN22047, was synthesized in 4 and 3 steps starting from 2,4-dihydroxy-6-methylbenzoic acid and 3,4,5-trihydroxytoluene, respectively. An effective ligand, 2-(di-tert-butyl-phosphino) biphenyl, was used in the palladium-catalyzed diaryl ether-forming reaction. Five analogous compounds of gerfelin were also synthesized for a study of the structure-activity relationship.

本文言語English
ページ(範囲)2523-2528
ページ数6
ジャーナルBioscience, Biotechnology and Biochemistry
70
10
DOI
出版ステータスPublished - 2006 11 6

ASJC Scopus subject areas

  • バイオテクノロジー
  • 分析化学
  • 生化学
  • 応用微生物学とバイオテクノロジー
  • 分子生物学
  • 有機化学

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