@article{d79ab203778b487fbc8ae17e1972802d,
title = "Synthesis of Peptidoglycan Fragments from Enterococcus faecalis with Fmoc-Strategy for Glycan Elongation",
abstract = "Peptidoglycan (PGN) is an essential structural component of the bacterial cell wall conferring cell shape, which can be recognized by host-recognition proteins and receptors as well as bacterial surface proteins. In this work, the PGN partial structures from Enterococcus faecalis that contain a tetrasaccharide and an octasaccharide with a unique heptapeptide were synthesized via an Fmoc-strategy for elongation of the glycan chains. Namely, a 4′-O-Fmoc-protected disaccharide was utilized as the key intermediate in this efficient synthetic pathway for preparing various PGN fragments. Both the tetrasaccharide and octasaccharide with the unique heptapeptide were successfully synthesized for the first time.",
keywords = "bioorganic chemistry, carbohydrates, glycosylation, peptides, peptidoglycan",
author = "Ning Wang and Hiroki Hasegawa and Huang, {Cheng Yuan} and Koichi Fukase and Yukari Fujimoto",
note = "Funding Information: The authors wish to thank Dr. St{\'e}phane Mesnage for his valuable suggestions on the structures of Enterococcus faecalis peptidoglycan. This work was supported in part by Grants-in-Aid for Scientific Research (Nos. JP26102732, JP26282211, and JP16H01162) from the Japan Society for the Promotion of Science (JSPS). We also received support from a funding program for Next Generation World-Leading Researchers (NEXT Program; LR025) run by JSPS and the Council for Science and Technology Policy, as well as from the Mizutani Foundation for Glycoscience. Publisher Copyright: {\textcopyright} 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2017",
month = jan,
day = "3",
doi = "10.1002/asia.201601357",
language = "English",
volume = "12",
pages = "27--30",
journal = "Chemistry - An Asian Journal",
issn = "1861-4728",
publisher = "John Wiley and Sons Ltd",
number = "1",
}