@article{575e107d4a864e5ab0141a8607e55b6f,
title = "Synthesis of Phosphatidylcholines Possessing Functionalized Acids at sn -2, and 13 C- 14 N and 13 C- 31 P Couplings in Their 13 C NMR Spectra",
abstract = "Although 4-Me 2 NC 5 H 4 N (DMAP) is a standard base for esterification of (2-Me-6-NO 2 -C 6 H 3 CO) 2 O (MNBA), N -methylimidazole (NMI) was examined for the condensation of acids with 1-stearoyl-lysophosphatidylcholine because of the non-tailing nature of NMI on silica gel. Acids tested were EPA, α-linolenic acid, TBS ethers of 18-HEPE and ricinoleic acid, acid-labile epoxy acids, and a phenyldiynyl acid. The condensation proceeded well with these acids, and chromatographic separation of resulting phosphatidylcholines and remaining NMI was easily performed. During the characterization of the products by 13 C NMR spectroscopy, 13 C- 14 N and 13 C- 31 P couplings were observed.",
keywords = "C- N coupling, N -methylimidazole, Shiina reagent, functionalized acid, lyso-phosphatidylcholine, synthesis",
author = "Masao Morita and Shun Saito and Riku Shinohara and Ryohei Aoyagi and Makoto Arita and Yuichi Kobayashi",
note = "Funding Information: This work was supported in part by the Japan Society for the Promotion of Science (JSPS KAKENHI, Grant No. JP15H05904 (Y.K.), JP15H05897 (M.A.), and JP15H05898 (M.A.).JapanSocietyforthePromotionofScience(JP15H05898)JapanSocietyforthePromotionofScience(JP15H05897)JapanSocietyforthePromotionofScience(JP15H05904) Publisher Copyright: {\textcopyright} 2020 Georg Thieme Verlag. All rights reserved.",
year = "2020",
month = apr,
day = "22",
doi = "10.1055/s-0039-1691584",
language = "English",
volume = "31",
pages = "718--722",
journal = "Synlett",
issn = "0936-5214",
publisher = "Georg Thieme Verlag",
number = "7",
}