Synthesis of Phosphatidylcholines Possessing Functionalized Acids at sn -2, and 13 C- 14 N and 13 C- 31 P Couplings in Their 13 C NMR Spectra

Masao Morita, Shun Saito, Riku Shinohara, Ryohei Aoyagi, Makoto Arita, Yuichi Kobayashi

研究成果: Article

抜粋

Although 4-Me 2 NC 5 H 4 N (DMAP) is a standard base for esterification of (2-Me-6-NO 2 -C 6 H 3 CO) 2 O (MNBA), N -methylimidazole (NMI) was examined for the condensation of acids with 1-stearoyl-lysophosphatidylcholine because of the non-tailing nature of NMI on silica gel. Acids tested were EPA, α-linolenic acid, TBS ethers of 18-HEPE and ricinoleic acid, acid-labile epoxy acids, and a phenyldiynyl acid. The condensation proceeded well with these acids, and chromatographic separation of resulting phosphatidylcholines and remaining NMI was easily performed. During the characterization of the products by 13 C NMR spectroscopy, 13 C- 14 N and 13 C- 31 P couplings were observed.

元の言語English
ページ(範囲)718-722
ページ数5
ジャーナルSynlett
31
発行部数7
DOI
出版物ステータスPublished - 2020 4 22

ASJC Scopus subject areas

  • Organic Chemistry

フィンガープリント Synthesis of Phosphatidylcholines Possessing Functionalized Acids at sn -2, and <sup>13</sup> C- <sup>14</sup> N and <sup>13</sup> C- <sup>31</sup> P Couplings in Their <sup>13</sup> C NMR Spectra' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用