Synthesis of Regioselectively Protected Forms of Cytidine Based on Enzyme-catalyzed Deacetylation as the Key Step

Atsuhito Kuboki, Takashi Ishihara, Eiko Kobayashi, Hiromichi Ohta, Takeshi Ishii, Ayumu Inoue, Satoshi Mitsuda, Tatsuo Miyazaki, Yasuhiro Kajihara, Takeshi Sugai

研究成果: Article査読

4 被引用数 (Scopus)

抄録

N4-Acetylcytidine (77%) and 2′,3′-O, N4-triacetylcytidine (95%) were obtained from the hydrolysis of a common precursor, the peracetylated form of cytidine with Aspergillus niger lipase (Amano A) and Burkholderia cepacia esterase (SC esterase S), respectively, under very mild conditions. The experimental procedure for the conversion of triacetylcytidine to a corresponding phosphoramidite (82%), an intermediate for sugar nucleotide synthesis, is also elaborated.

本文言語English
ページ(範囲)363-368
ページ数6
ジャーナルBioscience, Biotechnology and Biochemistry
64
2
DOI
出版ステータスPublished - 2000 1 1

ASJC Scopus subject areas

  • バイオテクノロジー
  • 分析化学
  • 生化学
  • 応用微生物学とバイオテクノロジー
  • 分子生物学
  • 有機化学

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