Synthesis of rocaglamide derivatives and evaluation of their Wnt signal inhibitory activities

Midori A. Arai, Yuuki Kofuji, Yuuki Tanaka, Natsuki Yanase, Kazuki Yamaku, Rolly G. Fuentes, Utpal Kumar Karmakar, Masami Ishibashi

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Rocaglamides are bioactive natural compounds which have a cyclopenta[b]benzofuran core structure. The total synthesis of a reported natural product, 3′-hydroxymethylrocaglate (5), was achieved using [3 + 2] cycloaddition between 3-hydroxyflavone and methyl cinnamate. We also describe the synthesis of rocaglamide heterocycle derivatives and evaluate their Wnt signal inhibitory activities. Compounds 4, 5, 22a, 22b, 22c and 23c showed potent Wnt signal inhibitory activity.

本文言語English
ページ(範囲)3061-3068
ページ数8
ジャーナルOrganic and Biomolecular Chemistry
14
11
DOI
出版ステータスPublished - 2016
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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