Synthesis of verbenachalcone congeners and their biological assessment against activation of the NGF-mediated neurite outgrowth of PC12D cells' activity

Takamasa Tanabe, Takahisa Ogamino, Yoshifumi Shimizu, Masaya Imoto, Shigeru Nishiyama

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Synthesis of the verbenachalcone derivatives 3-5 involving littorachalcone 2 from diaryl ether 7 enabled an SAR study of enhancement activity against the NGF-mediated neurite outgrowth from PC12D cells. Littorachalcone 2 and o-deoxyverbenachalcone 5 showed similar activity to that of verbenachalcone 1.

本文言語English
ページ(範囲)2753-2762
ページ数10
ジャーナルBioorganic and Medicinal Chemistry
14
8
DOI
出版ステータスPublished - 2006 4 15

ASJC Scopus subject areas

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬科学
  • 創薬
  • 臨床生化学
  • 有機化学

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