Synthesis, radical scavenging activity and structure-activity relationship of uric acid analogs

Daisuke Yasuda, Kyoko Takahashi, Tomohiro Kakinoki, Yoko Tanaka, Tomoyuki Ohe, Shigeo Nakamura, Tadahiko Mashino

研究成果: Article

12 引用 (Scopus)

抜粋

Uric acid (UA) is known to play an important role as an endogenous antioxidant. However, its insolubility in the serum is a risk for hyperuricemia. We assume that UA is an equivalent to hydroquinone or p-aminophenol, which can be oxidized to quinone/quinoimine and thus acts as a radical scavenger. Based on this hypothesis, a series of UA analogs was designed and synthesized. In the chemical radical scavenging assay, active compounds were considered as hydroquinone or p-aminophenol equivalents. A highly functionalized UA structure is not essential to have radical scavenging activity. Potent active 5-hydroxyindolinones (1a, 2a, and 3a) showed sufficient activity with high solubility and low cytotoxicity.

元の言語English
ページ(範囲)527-529
ページ数3
ジャーナルMedChemComm
4
発行部数3
DOI
出版物ステータスPublished - 2013 3 1

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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