Synthesis, radical scavenging activity and structure-activity relationship of uric acid analogs

Daisuke Yasuda, Kyoko Takahashi, Tomohiro Kakinoki, Yoko Tanaka, Tomoyuki Ohe, Shigeo Nakamura, Tadahiko Mashino

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Uric acid (UA) is known to play an important role as an endogenous antioxidant. However, its insolubility in the serum is a risk for hyperuricemia. We assume that UA is an equivalent to hydroquinone or p-aminophenol, which can be oxidized to quinone/quinoimine and thus acts as a radical scavenger. Based on this hypothesis, a series of UA analogs was designed and synthesized. In the chemical radical scavenging assay, active compounds were considered as hydroquinone or p-aminophenol equivalents. A highly functionalized UA structure is not essential to have radical scavenging activity. Potent active 5-hydroxyindolinones (1a, 2a, and 3a) showed sufficient activity with high solubility and low cytotoxicity.

本文言語English
ページ(範囲)527-529
ページ数3
ジャーナルMedChemComm
4
3
DOI
出版ステータスPublished - 2013 3 1

ASJC Scopus subject areas

  • 生化学
  • 分子医療
  • 薬理学
  • 薬科学
  • 創薬
  • 有機化学

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