Synthetic Access to gem-Difluoropropargyl Vinyl Ethers and Their Application to Propargyl Claisen Rearrangement

Toshitaka Okamura, Kenta Koyamada, Junichiro Kanazawa, Kazunori Miyamoto, Yoshiharu Iwabuchi, Masanobu Uchiyama, Naoki Kanoh

研究成果: Article査読

1 被引用数 (Scopus)

抄録

With the increasing importance of fluorine to medicinal chemistry and other areas, methods to access various fluorinated compounds are needed. Herein, we report the synthesis of difluoropropargyl vinyl ethers from ketones and aldehydes using difluoropropargyl bromide dicobalt complexes. We applied difluoropropargyl vinyl ethers to the synthesis of difluorodienone or difluoroallene under thermal conditions and trifluoro-pyran under acid-catalyzed conditions.

本文言語English
ページ(範囲)1911-1924
ページ数14
ジャーナルJournal of Organic Chemistry
86
2
DOI
出版ステータスPublished - 2021 1月 15
外部発表はい

ASJC Scopus subject areas

  • 有機化学

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