The development of coelenterazine (CTZ) derivatives resulting in superior optical characteristics is an efficient method to extend the range of its possible applications. Here, we describe the synthesis of three C-6 substituted CTZ derivatives retaining the recognition by Renilla luciferase (RLuc) and its derivatives. The novel derivatives are useful as bright blue-shifted CTZ derivatives, which can be used as an alternative to hitherto reported compound DeepBlueC™.
|ホスト出版物のタイトル||Methods in Molecular Biology|
|出版社||Humana Press Inc.|
|出版ステータス||Published - 2016|
|名前||Methods in Molecular Biology|
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