@article{baac19de3c6146099234470db9a485e7,
title = "Synthetic studies on apoptolidin: Synthesis of the C12-C28 fragment via a highly stereoselective aldol reaction",
abstract = "The stereoselective and convergent synthesis of the C12-C28 segment 2 of the apoptosis inducing macrolide antibiotic, apoptolidin (1), is described. The synthesis involves a highly stereoselective tin(II)-mediated aldol reaction between the C17-C22 ethyl ketone 3 and the C23-C28 aldehyde 4 as the key step.",
keywords = "Aldol reaction, Antibiotic, Apoptolidin, Apoptosis, Macrolide",
author = "Kazuyuki Abe and Koji Kato and Tadamasa Arai and Rahim, {Mohammad Abdur} and Israt Sultana and Shuichi Matsumura and Kazunobu Toshima",
note = "Funding Information: This research was supported in part by Grant-in-Aid for the 21st Century COE program {\textquoteleft}KEIO Life Conjugate Chemistry{\textquoteright} from the Ministry of Education, Culture, Sports, Science, and Technology, Japan. M.A.R. thanks to the JSPS Postdoctoral Fellowship for Foreign Researchers and Grant-in Aid for JSPS Fellows from Japan Society for the Promotion of Science.",
year = "2004",
month = nov,
day = "22",
doi = "10.1016/j.tetlet.2004.09.177",
language = "English",
volume = "45",
pages = "8849--8853",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "48",
}