Synthetic Studies on FNC-RED and Its Analogues Containing an All syn-Cyclopentanetetrol Moiety

Shinsuke Inuki; Keisuke Sato; Naoto Zui; Ryosuke Yamaguchi; Takanori Matsumaru; Yukari Fujimoto

doi:10.1021/acs.joc.9b02101

Synthetic Studies on FNC-RED and Its Analogues Containing an All syn-Cyclopentanetetrol Moiety

Shinsuke Inuki, Keisuke Sato, Naoto Zui, Ryosuke Yamaguchi, Takanori Matsumaru, Yukari Fujimoto

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研究成果: Article › 査読

1 被引用数 (Scopus)

抄録

FNC-RED exhibits innate immune receptor Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD2) stimulatory activity. We have developed a divergent synthetic route to FNC-RED derivatives containing various alkyl side chains. Key features of the synthetic study include stepwise palladium catalyzed cross-coupling reactions and the construction of an all syn-cyclopentanetetrol moiety.

本文言語	English
ページ（範囲）	12680-12685
ページ数	6
ジャーナル	Journal of Organic Chemistry
巻	84
号	19
DOI	https://doi.org/10.1021/acs.joc.9b02101
出版ステータス	Published - 2019 10月 4

ASJC Scopus subject areas

有機化学

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10.1021/acs.joc.9b02101

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abstract = "FNC-RED exhibits innate immune receptor Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD2) stimulatory activity. We have developed a divergent synthetic route to FNC-RED derivatives containing various alkyl side chains. Key features of the synthetic study include stepwise palladium catalyzed cross-coupling reactions and the construction of an all syn-cyclopentanetetrol moiety.",

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AU - Yamaguchi, Ryosuke

AU - Matsumaru, Takanori

AU - Fujimoto, Yukari

PY - 2019/10/4

Y1 - 2019/10/4

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AB - FNC-RED exhibits innate immune receptor Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD2) stimulatory activity. We have developed a divergent synthetic route to FNC-RED derivatives containing various alkyl side chains. Key features of the synthetic study include stepwise palladium catalyzed cross-coupling reactions and the construction of an all syn-cyclopentanetetrol moiety.

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Synthetic Studies on FNC-RED and Its Analogues Containing an All syn-Cyclopentanetetrol Moiety

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