Synthetic studies on glycosphingolipids from protostomia phyla: Synthesis of glycosphingolipids from the parasite Schistosoma mansoni

Takayuki Kanaya, Satomi Yagi, Frank Schweizer, Tadahiro Takeda, Fumiyuki Kiuchi, Noriyasu Hada

研究成果: Article査読

8 被引用数 (Scopus)

抄録

Synthetic access to three neutral glycosphingolipids from the parasite Schistosoma mansoni adult worm has been achieved. These structures differ significantly from those of other parasites and exhibit a unique structural motif termed "schisto-core" consisting of GalNAcb 1→4Glcβ 1→sequence. We have synthesized glycosphi-ngolipids, β-D-GalNAcp- (1→4)-β-D-Glcp-(1→1)Cer (1), β-D-GlcNAcp-(1→3)-β- D-GalNAcp-(1→4)-β-D-Glcp-(1→1)Cer (2) and β-D-Galp- (1→4)-β-D-GlcNAcp-(1→3)-β-D-GalNAcp-(1→4) -β-D-Glcp-(1→1)Cer (3).

本文言語English
ページ(範囲)811-817
ページ数7
ジャーナルChemical and Pharmaceutical Bulletin
58
6
DOI
出版ステータスPublished - 2010 6月

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

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