Synthetic studies on glycosphingolipids from Protostomia phyla: Total syntheses of glycosphingolipids from the parasite, Echinococcus multilocularis

Takeshi Yamamura, Noriyasu Hada, Asuka Kaburaki, Kimiaki Yamano, Tadahiro Takeda

研究成果: Article査読

30 被引用数 (Scopus)

抄録

Efficient and systematic syntheses of four neutral glycosphingolipids that have been isolated from the metacestodes of Echinococcus multilocularis have been achieved. A key step is the direct glycosylation of galactosyl donors using thioglycosides with benzoyl ceramide in the presence of N-iodosuccinimide (NIS)/TfOH, which gave the desired oligosaccharide derivatives. The fully protected glycosides 13, 20, 22 and 25 were deprotected to give four target glycosphingolipids (1-4).

本文言語English
ページ(範囲)2749-2759
ページ数11
ジャーナルCarbohydrate Research
339
17
DOI
出版ステータスPublished - 2004 12月 6
外部発表はい

ASJC Scopus subject areas

  • 分析化学
  • 生化学
  • 有機化学

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