Synthetic studies on glycosphingolipids from the parasite Echinococcus multilocularis

Noriyasu Hada, Eriko Hayashi, Tadahiro Takeda

研究成果: Article査読

22 被引用数 (Scopus)

抄録

Novel neutral glycosphingolipids isolated from the metacestodes of Echinococcus multilocularis by Persat, may be expected to be involved in host-parasite interactions. We have synthesized these glycosphingolipid analogues containing 2-branched fatty alkyl residues in place of ceramide. The glycosylation of galactosyl donors 4 and 5 with each of the acceptors 2 and 11 in the presence of N-iodosuccinimide (NIS)/TfOH, and the glycosylation of fucosyl donor 13 with acceptors 12 and 20 in the presence of dimethyl(methylthio)sulfonium triflate (DMTST) gave the desired oligosaccharide derivatives at good yield. The fully per-O-acylated 2-(trimethylsilyl)ethyl glycosides 6, 15, 21, and 26 were converted to glycosylimidates 7, 16, 22, and 27, which were condensed with 2-(tetradecyl)hexadecanol and subsequently deacylated give four target glycosphingolipid analogues. Copyright (C) 1999 Elsevier Science Ltd.

本文言語English
ページ(範囲)58-70
ページ数13
ジャーナルCarbohydrate Research
316
1-4
DOI
出版ステータスPublished - 1999 3 15

ASJC Scopus subject areas

  • 分析化学
  • 生化学
  • 有機化学

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