Synthetic studies on polymaxenolides: Model studies for constructing dihydropyran portion and synthesis of lower portion

Yutaka Matsuda, Masaya Kato, Tomonori Kawaguchi, Takayuki Koyama, Yoko Saikawa, Masaya Nakata

研究成果: Article査読

7 被引用数 (Scopus)

抄録

With a goal of the total synthesis of polymaxenolide, the first hybrid marine natural product, the model studies for constructing the dihydropyran portion based on the originally proposed biosynthesis (C-C bond formation followed by dehydrative cyclization) and the synthesis of the lower portion (the C1-C3, C7-C17 portion) based on an iodide-induced Morita-Baylis-Hillman type reaction (a three-component assembly) followed by Suzuki-Miyaura cross-coupling are described.

本文言語English
ページ(範囲)1154-1168
ページ数15
ジャーナルTetrahedron
70
6
DOI
出版ステータスPublished - 2014 2 11

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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