TY - JOUR
T1 - Synthetic studies on polymaxenolides
T2 - Model studies for constructing dihydropyran portion and synthesis of lower portion
AU - Matsuda, Yutaka
AU - Kato, Masaya
AU - Kawaguchi, Tomonori
AU - Koyama, Takayuki
AU - Saikawa, Yoko
AU - Nakata, Masaya
N1 - Funding Information:
This research was partially supported by a ‘MEXT-Supported Program for the Strategic Research Foundation at Private Universities 2012–2016’.
PY - 2014/2/11
Y1 - 2014/2/11
N2 - With a goal of the total synthesis of polymaxenolide, the first hybrid marine natural product, the model studies for constructing the dihydropyran portion based on the originally proposed biosynthesis (C-C bond formation followed by dehydrative cyclization) and the synthesis of the lower portion (the C1-C3, C7-C17 portion) based on an iodide-induced Morita-Baylis-Hillman type reaction (a three-component assembly) followed by Suzuki-Miyaura cross-coupling are described.
AB - With a goal of the total synthesis of polymaxenolide, the first hybrid marine natural product, the model studies for constructing the dihydropyran portion based on the originally proposed biosynthesis (C-C bond formation followed by dehydrative cyclization) and the synthesis of the lower portion (the C1-C3, C7-C17 portion) based on an iodide-induced Morita-Baylis-Hillman type reaction (a three-component assembly) followed by Suzuki-Miyaura cross-coupling are described.
KW - Dehydrative cyclization
KW - Morita-Baylis-Hillman reaction
KW - Polymaxenolide
KW - Suzuki-Miyaura cross-coupling
UR - http://www.scopus.com/inward/record.url?scp=84892782737&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892782737&partnerID=8YFLogxK
U2 - 10.1016/j.tet.2013.12.076
DO - 10.1016/j.tet.2013.12.076
M3 - Article
AN - SCOPUS:84892782737
SN - 0040-4020
VL - 70
SP - 1154
EP - 1168
JO - Tetrahedron
JF - Tetrahedron
IS - 6
ER -
