Synthetic studies on thiostrepton family of peptide antibiotics: Synthesis of the pentapeptide segment containing dihydroxyisoleucine, thiazoline and dehydroamino acid

Shuhei Higashibayashi, Mitsunori Kohno, Taiji Goto, Kengo Suzuki, Tomonori Mori, Kimiko Hashimoto, Masaya Nakata

研究成果: Article査読

34 被引用数 (Scopus)

抄録

The dihydroxyisoleucine-, thiazoline- and dehydroamino acid-containing pentapeptide of the thiostrepton family of peptide antibiotics was synthesized, which featured the β-lactone opening by phenylselenylation, the vinylzinc addition to the chiral sulfinimine, the Wipf oxazoline-thiazoline conversion method and the oxidative syn-elimination of the phenylseleno group.

本文言語English
ページ(範囲)3707-3712
ページ数6
ジャーナルTetrahedron Letters
45
19
DOI
出版ステータスPublished - 2004 5月 3

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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