抄録
Low-molecular weight type I and II fucoidan derivatives with different sulfation patterns were designed and systematically synthesized from the corresponding common key intermediate and their anti-proliferative activities and apoptosis-inducing activities against human breast cancer (MCF-7) and human cervical epithelioid carcinoma (HeLa) cells were evaluated. Our results demonstrated that one of the type II fucoidan derivatives, 9, effectively reduced the number of viable MCF-7 and HeLa cells in a dose-dependent manner without causing cytotoxicity toward normal WI-38 cells, and that the anti-proliferative activity of 9 was comparable to that of fucoidan 2 isolated from Fucus vesiculosus. Moreover, it was found that both 2 and 9 exhibited similar apoptosis-inducing activities through activation of caspase-8 and -9 on MCF-7 and HeLa cells, respectively.
本文言語 | English |
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ページ(範囲) | 10556-10568 |
ページ数 | 13 |
ジャーナル | Organic and Biomolecular Chemistry |
巻 | 13 |
号 | 42 |
DOI | |
出版ステータス | Published - 2015 |
ASJC Scopus subject areas
- 生化学
- 物理化学および理論化学
- 有機化学