Systematic synthesis of sulfated oligofucosides and their effect on breast cancer MCF-7 cells

Shinsuke Arafuka, Nozomi Koshiba, Daisuke Takahashi, Kazunobu Toshima

研究成果: Article査読

14 被引用数 (Scopus)

抄録

Sulfated tetrafucosides 2–5 with different sulfation patterns, and a non-sulfated tetrafucoside 6, were designed and systematically synthesized from the common key intermediate 12 . In addition, their anti-proliferative activities and apoptosis-inducing activities against human breast cancer MCF-7 cells were evaluated. Our results demonstrated that the sulfated tetrafucosides 2–4 reduced the number of MCF-7 cells in a dose-dependent manner, and of these, 3,4- O -sulfated type 4 showed the highest anti-proliferative activity, comparable to the activity of fucoidan 1 isolated from Fucus vesiculosus . Furthermore, it was revealed that both 1 and 4 exhibited apoptosis-inducing activities through activation of caspase-8 on MCF-7 cells.

本文言語English
ページ(範囲)9831-9834
ページ数4
ジャーナルChemical Communications
50
69
DOI
出版ステータスPublished - 2014 7 31

ASJC Scopus subject areas

  • 触媒
  • 電子材料、光学材料、および磁性材料
  • セラミックおよび複合材料
  • 化学 (全般)
  • 表面、皮膜および薄膜
  • 金属および合金
  • 材料化学

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