Systemic lupus erythematosus with necrotizing vasculitis and upregulated expression of VLA-4 antigen

Tsutomu Takeuchi, K. Aoki, J. Koide, H. Sekine, T. Abe

研究成果: Article

8 引用 (Scopus)

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We report on a patient (S.A.), with well-defind SLE who developed a perforation of the ileum due to pathologically confirmed necrotizing vasculitis. No anti-DNA antibody was detected at the ileal perforation, and the serum complement level was normal. These findings rais ethe alternative possibility of a cellmediated immune mechanism as a cause of necrotizing vaculitis. Upregulateed expression and function of VLA-4 antigen on peripheral blood T cells were oberved, suggesting that T cells with VLA-4 antigen may participate in the onset and/or perpetuation of vascular inflammation.

元の言語English
ページ(範囲)370-374
ページ数5
ジャーナルClinical Rheumatology
14
発行部数3
DOI
出版物ステータスPublished - 1995 5
外部発表Yes

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ASJC Scopus subject areas

  • Rheumatology
  • Immunology

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