Target identification of bioactive compounds

Etsu Tashiro, Masaya Imoto

研究成果: Article査読

24 被引用数 (Scopus)

抄録

To fully understand the regulation of cellular events, functional analysis of each protein involved in the regulatory systems is required. Among a variety of methods to uncover protein function, chemical genetics is a remarkable approach in which small molecular compounds are used as probes to elucidate protein functions within signaling pathways. However, identifying the target of small molecular bioactive compounds isolated by cell-based assays represents a crucial hurdle that must be overcome before chemical genetic studies can commence. A variety of methods and technologies for identifying target proteins have been reported. This review therefore aims to describe approaches for identifying these molecular targets.

本文言語English
ページ(範囲)1910-1921
ページ数12
ジャーナルBioorganic and Medicinal Chemistry
20
6
DOI
出版ステータスPublished - 2012 3 15

ASJC Scopus subject areas

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬科学
  • 創薬
  • 臨床生化学
  • 有機化学

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