@article{4c2b365f72674a77902e7f5b5b558f5d,
title = "Target protein-oriented isolations for bioactive natural products",
abstract = "Natural products are very attractive for development of medicine. Their structure and bioactivities are often beyond human knowledge and imagination. We have developed isolation methods for target protein-oriented natural products so as quickly to discover bioactive compounds from natural resources. This review summarizes our recent results including protein beads methods for neural stem cells differentiation activators and new cancer drug candidates. Syntheses of isolated compounds are described. We also developed protein plate method for identification of protein-protein interaction inhibitors. Because protein binding ability is tightly related to bioactivity, protein-based natural products isolation is a powerful means to find new candidate medicines.",
keywords = "Cancer cell, Natural product, Neural stem cell, Protein bead, Protein plate",
author = "Arai, {Midori A.}",
note = "Funding Information: Acknowledgments I am grateful to Prof. Masami Ishi-bashi for generous guidance and encouragement in achieving the results described in this review. I express my sincere thanks to my collaborators. This study was supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (JSPS). Funding Information: Midori A. Arai was born in Miyazaki, Japan in 1972. She obtained her Ph.D. degree at the University of Tokyo, Japan (advisor: Masakatsu Shibasaki) in 2000. She worked at Osaka University in 2000–03 (advisor: Prof. Hiroaki Sasai), Harvard University in 2001–02 (advisor: Prof. Stuart L. Schreiber), and RIKEN in 2003–04 (advisor: Dr. Yukishige Ito) as a postdoctoral fellow. She became an assistant professor in Teikyo University in 2004. In 2006, she was appointed associate professor at Chiba University. She was promoted to Professor at Keio University in 2020. She worked as a visiting associate professor at Institute for Chemical Research, Kyoto University in 2010. She also worked as a program officer, Grants-in-Aid for Scientific Research (KAKENHI), Ministry of Education, Culture, Sports, Science and Technology-Japan in 2013–15. She has received several awards such as the Pharmaceutical Society of Japan Award for Young Scientists in 2010, the Morita award of Japanese Association of University Women in 2011, Asian Core Program Lectureship Award in 2012, the Society of Japanese Women Scientists (SJWS) Promoting Scientific Award in 2014, and the Pharmaceutical Society of Japan Award for Divisional Scientific Promotion in 2019. Publisher Copyright: {\textcopyright} 2021 The Pharmaceutical Society of Japan",
year = "2021",
month = jun,
day = "1",
doi = "10.1248/cpb.c21-00040",
language = "English",
volume = "69",
pages = "503--515",
journal = "Chemical and Pharmaceutical Bulletin",
issn = "0009-2363",
publisher = "Pharmaceutical Society of Japan",
number = "6",
}
