Target protein-oriented isolations for bioactive natural products

研究成果: Review article査読

抄録

Natural products are very attractive for development of medicine. Their structure and bioactivities are often beyond human knowledge and imagination. We have developed isolation methods for target protein-oriented natural products so as quickly to discover bioactive compounds from natural resources. This review summarizes our recent results including protein beads methods for neural stem cells differentiation activators and new cancer drug candidates. Syntheses of isolated compounds are described. We also developed protein plate method for identification of protein-protein interaction inhibitors. Because protein binding ability is tightly related to bioactivity, protein-based natural products isolation is a powerful means to find new candidate medicines.

本文言語English
ページ(範囲)503-515
ページ数13
ジャーナルChemical and Pharmaceutical Bulletin
69
6
DOI
出版ステータスPublished - 2021 6 1

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

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