Target-selective degradation of proteins by a light-activated 2-phenylquinoline-estradiol hybrid

Akane Suzuki; Kana Tsumura; Takeo Tsuzuki; Shuichi Matsumura; Kazunobu Toshima

doi:10.1039/b708947c

Target-selective degradation of proteins by a light-activated 2-phenylquinoline-estradiol hybrid

Akane Suzuki, Kana Tsumura, Takeo Tsuzuki, Shuichi Matsumura, Kazunobu Toshima

応用化学科

研究成果: Article › 査読

18 被引用数 (Scopus)

抄録

A designed 2-phenylquinoline-estradiol hybrid effectively and selectively degraded the target transcription factor, human estrogen receptor-α (hER-α), which has a high affinity with the estradiol moiety, under long-wavelength UV photo-irradiation, without additives and under neutral conditions.

本文言語	English
ページ（範囲）	4260-4262
ページ数	3
ジャーナル	Chemical Communications
号	41
DOI	https://doi.org/10.1039/b708947c
出版ステータス	Published - 2007 1月 1

ASJC Scopus subject areas

触媒
電子材料、光学材料、および磁性材料
セラミックおよび複合材料
化学 (全般)
表面、皮膜および薄膜
金属および合金
材料化学

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10.1039/b708947c

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AU - Toshima, Kazunobu

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Target-selective degradation of proteins by a light-activated 2-phenylquinoline-estradiol hybrid

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