Target-Selective Fluorescence Imaging and Photocytotoxicity against H2O2 High-Expressing Cancer Cells Using a Photoactivatable Theranostic Agent

Ryoma Takagi, Ayano Takeda, Daisuke Takahashi, Kazunobu Toshima

研究成果: Article査読

10 被引用数 (Scopus)

抄録

A purpose-designed and synthesized H2O2-reactive and photoactivatable theranostic agent 1 consisting of 1) an arylboronic acid moiety, 2) pro-fluorophore moiety, and 3) photoactivatable moiety (photosensitizer), selectively and effectively reacted with H2O2 while simultaneously releasing resorufin for fluorescence detection under neutral aqueous conditions. In addition, 1 was cell-permeable, and exhibited effective photocytotoxicity against fluorescently visualized cells only upon photoirradiation. The results also showed that 1 produced a selective fluorescence response to H2O2, even in living cultured cells.

本文言語English
ページ(範囲)2656-2659
ページ数4
ジャーナルChemistry - An Asian Journal
12
20
DOI
出版ステータスPublished - 2017 10月 18

ASJC Scopus subject areas

  • 生化学
  • 有機化学

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