Target-selective photo-degradation of a sialyl Lewis a (sLea) conjugate and photo-cytotoxicity against sLea positive cancer cells using an anthraquinone-antibody hybrid

Daisuke Takahashi, Takashi Nagao, Shota Sotokawa, Kazunobu Toshima

研究成果: Article査読

2 被引用数 (Scopus)

抄録

A purpose-designed anthraquinone-monoclonal antibody (anti-sialyl Lewis A (sLea) mAb) hybrid 6 selectively bound to and effectively degraded the target glycoprotein, HSA (human serum albumin)-sLea conjugate 4. Degradation was achieved using long wavelength UV light irradiation in the absence of any additives and under neutral conditions. Furthermore, the hybrid 6 exhibited selective photo-cytotoxicity against the sLea positive cancer cells A431 and WiDr cells only upon photo-irradiation.

本文言語English
ページ(範囲)1224-1228
ページ数5
ジャーナルMedChemComm
7
6
DOI
出版ステータスPublished - 2016

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

フィンガープリント 「Target-selective photo-degradation of a sialyl Lewis a (sLe<sup>a</sup>) conjugate and photo-cytotoxicity against sLe<sup>a</sup> positive cancer cells using an anthraquinone-antibody hybrid」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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