抄録
A purpose-designed anthraquinone-monoclonal antibody (anti-sialyl Lewis A (sLea) mAb) hybrid 6 selectively bound to and effectively degraded the target glycoprotein, HSA (human serum albumin)-sLea conjugate 4. Degradation was achieved using long wavelength UV light irradiation in the absence of any additives and under neutral conditions. Furthermore, the hybrid 6 exhibited selective photo-cytotoxicity against the sLea positive cancer cells A431 and WiDr cells only upon photo-irradiation.
本文言語 | English |
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ページ(範囲) | 1224-1228 |
ページ数 | 5 |
ジャーナル | MedChemComm |
巻 | 7 |
号 | 6 |
DOI | |
出版ステータス | Published - 2016 |
ASJC Scopus subject areas
- 生化学
- 分子医療
- 薬理学
- 薬科学
- 創薬
- 有機化学