Target-selective photodegradation of HIV-1 protease and inhibition of HIV-1 replication in living cells by designed fullerene-sugar hybrids

Shuho Tanimoto, Satoshi Sakai, Eriko Kudo, Seiji Okada, Shuichi Matsumura, Daisuke Takahashi, Kazunobu Toshima

研究成果: Article査読

21 被引用数 (Scopus)

抄録

Sweet degradation: A designed fullerene-sugar hybrid selectively caused the degradation of HIV-1 protease, an important target of anti-HIV therapy. Degradation was achieved at irradiation with long-wavelength UV (365 nm) or visible light (diffuse sunlight) in the absence of any additives and under neutral conditions. Moreover, the hybrid inhibited HIV-1 replication in living cells infected with HIV-1.

本文言語English
ページ(範囲)911-914
ページ数4
ジャーナルChemistry - An Asian Journal
7
5
DOI
出版ステータスPublished - 2012 5

ASJC Scopus subject areas

  • 生化学
  • 有機化学

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