Targeting mitochondrial ATP-sensitive potassium channels - A novel approach to neuroprotection

David W. Busija, Zsombor Lacza, Nishadi Rajapakse, Katsuyoshi Shimizu, Béla Kis, Ferenc Bari, Ferenc Domoki, Takashi Horiguchi

研究成果: Review article

119 引用 (Scopus)

抜粋

Mitochondrial responses to ischemic stress play an important role in necrosis and apoptosis of brain cells. Recent studies using several different experimental preparations have shown that activation of ATP-sensitive potassium channels in mitochondria (mitoK ATP channels) is able to protect neurons and astroglia against injury and death. Thus, targeting of mitoK ATP channels appears to be a novel approach to neuroprotection. However, little is known about the mechanisms involved. The purpose of this review is to detail the current state of knowledge about this important, emerging area of investigation, and to provide suggestions for future studies.

元の言語English
ページ(範囲)282-294
ページ数13
ジャーナルBrain Research Reviews
46
発行部数3
DOI
出版物ステータスPublished - 2004 11 1
外部発表Yes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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