抄録
A new NF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), inhibited proliferation and induced apoptosis in human Burkitt lymphoma, HS-Sultan and Daudi cell lines. The activation of caspase-3 and the cleavage of caspase substrate PARP were observed after treatment with DHMEQ. The induction of apoptosis by DHMEQ was prevented by the pretreatment of Burkitt lymphoma cells with pan-caspase inhibitor, z-VAD-FMK. The expression of anti-apoptotic factors such as IAP-1 and XIAP was suppressed by DHMEQ. Phosphorylation of ERK and JNK was induced by DHMEQ. In conclusion, these results demonstrate that NF-κB might be an ideal target to develop for new anti-cancer drugs for Burkitt lymphoma.
本文言語 | English |
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ページ(範囲) | 1529-1535 |
ページ数 | 7 |
ジャーナル | Leukemia Research |
巻 | 31 |
号 | 11 |
DOI | |
出版ステータス | Published - 2007 11月 1 |
ASJC Scopus subject areas
- 血液学
- 腫瘍学
- 癌研究