Tau Oligomers

Sumihiro Maeda, Akihiko Takashima

研究成果: Chapter

抄録

The accumulation of tau filaments in neurons is a pathological hallmark of various neurodegenerative diseases, including Alzheimer’s disease. However, it is not the filamentous aggregates themselves, but non-filamentous tau species, tau oligomer, that is thought to be the culprit in tau-mediated neurodegeneration. The definition of and methodology for isolating tau oligomers vary among researchers. Here we describe how tau oligomers are identified, summarize the differences of tau oligomers among research groups, and discuss their hypothesized functions.

本文言語English
ホスト出版物のタイトルAdvances in Experimental Medicine and Biology
出版社Springer
ページ373-380
ページ数8
DOI
出版ステータスPublished - 2019 1 1

出版物シリーズ

名前Advances in Experimental Medicine and Biology
1184
ISSN(印刷版)0065-2598
ISSN(電子版)2214-8019

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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