Technetium-99m complexes with steroid-2-aminooxyethyliminodiacetic acid conjugates

Reiko Yoda, Yoshiharu Karube, Jiro Takata, Yoshiko Nagata, Yoshikazu Matsushima

研究成果: Article

3 被引用数 (Scopus)

抄録

Conjugates of 2-aminooxyethyliminodiacetic acid with estrone, testosterone, epiandrosterone, 17-α-hydroxy-progesterone and progesterone were synthesized and their complexes with Tc-99m were successfully prepared in good yields, which indicated the agent to be promising for metal-labeling of biomolecules and related substances containing one or more carbonyl groups. The biodistribution and scintigraphic studies in mice bearing Ehrlich tumor and mammary tumor showed that the radioactivity accumulated considerably in the tumor tissues, but the tumor images were somewhat obscured.

本文言語English
ページ(範囲)413-416
ページ数4
ジャーナルChemical and Pharmaceutical Bulletin
47
3
DOI
出版ステータスPublished - 1999 3

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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