抄録
Background: The contribution of TERT to cellular reprogramming is unclear. Results: KO of TERT reduces the reprogramming efficiency of somatic cells, and continuous growth induces chromosome abnormalities; enzymatically inactive TERT rescues the efficiency. Conclusion: TERT has a telomerase-independent role in somatic cell reprogramming. Significance: Understanding the cellular reprogramming process is crucial for the clinical applications of induced pluripotent stem cells.
本文言語 | English |
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ページ(範囲) | 15776-15787 |
ページ数 | 12 |
ジャーナル | Journal of Biological Chemistry |
巻 | 289 |
号 | 22 |
DOI | |
出版ステータス | Published - 2014 5月 30 |
ASJC Scopus subject areas
- 生化学
- 分子生物学
- 細胞生物学