Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming

Taisuke Kinoshita, Go Nagamatsu, Shigeru Saito, Keiyo Takubo, Katsuhisa Horimoto, Toshio Suda

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Background: The contribution of TERT to cellular reprogramming is unclear. Results: KO of TERT reduces the reprogramming efficiency of somatic cells, and continuous growth induces chromosome abnormalities; enzymatically inactive TERT rescues the efficiency. Conclusion: TERT has a telomerase-independent role in somatic cell reprogramming. Significance: Understanding the cellular reprogramming process is crucial for the clinical applications of induced pluripotent stem cells.

本文言語English
ページ(範囲)15776-15787
ページ数12
ジャーナルJournal of Biological Chemistry
289
22
DOI
出版ステータスPublished - 2014 5 30

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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