Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming

Taisuke Kinoshita; Go Nagamatsu; Shigeru Saito; Keiyo Takubo; Katsuhisa Horimoto; Toshio Suda

doi:10.1074/jbc.M113.536037

Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming

Taisuke Kinoshita, Go Nagamatsu, Shigeru Saito, Keiyo Takubo, Katsuhisa Horimoto, Toshio Suda

坂口光洋記念講座(発生・分化生物学)

研究成果: Article › 査読

14 被引用数 (Scopus)

抄録

Background: The contribution of TERT to cellular reprogramming is unclear. Results: KO of TERT reduces the reprogramming efficiency of somatic cells, and continuous growth induces chromosome abnormalities; enzymatically inactive TERT rescues the efficiency. Conclusion: TERT has a telomerase-independent role in somatic cell reprogramming. Significance: Understanding the cellular reprogramming process is crucial for the clinical applications of induced pluripotent stem cells.

本文言語	English
ページ（範囲）	15776-15787
ページ数	12
ジャーナル	Journal of Biological Chemistry
巻	289
号	22
DOI	https://doi.org/10.1074/jbc.M113.536037
出版ステータス	Published - 2014 5月 30

ASJC Scopus subject areas

生化学
分子生物学
細胞生物学

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10.1074/jbc.M113.536037

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AU - Horimoto, Katsuhisa

AU - Suda, Toshio

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Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming

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