Telomere length of normal leukocytes is affected by a functional polymorphism of hTERT

Yumiko Matsubara, Mitsuru Murata, Tadashi Yoshida, Kiyoaki Watanabe, Ikuo Saito, Koichi Miyaki, Kazuyuki Omae, Yasuo Ikeda

研究成果: Article査読

59 被引用数 (Scopus)

抄録

Transcriptional regulation of human telomerase reverse transcriptase (hTERT), a catalytic subunit of telomerase, is essential for telomerase activity associated with telomere length. In this study, we investigated the effects of a -1327T/C polymorphism within the hTERT promoter region on the hTERT promoter activity and leukocyte telomere length in normal individuals. The promoter activity in the -1327T-sequence was significantly higher than that in the -1327C-sequence (p = 0.0004). For leukocyte telomere length, the -1327T-allele carriers had significantly longer than the -1327T-allele non-carriers (p = 0.0007). Also, there was no age-related shortening in leukocyte telomere length in the -1327T/T (p = 0.6633) and -1327T/C subjects (p = 0.1691), whereas there was clear age-related telomere shortening in the -1327C/C subjects (p = 0.0117). These findings suggest that the functional -1327T/C polymorphism of hTERT is associated with leukocyte telomere length in normal individuals.

本文言語English
ページ(範囲)128-131
ページ数4
ジャーナルBiochemical and Biophysical Research Communications
341
1
DOI
出版ステータスPublished - 2006 3 3

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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