TY - JOUR
T1 - Temperature-Dependent Dynamics of Giant Vesicles Composed of Hydrolysable Lipids Having an Amide Linkage
AU - Tameyuki, Maito
AU - Hiranaka, Hisato
AU - Toyota, Taro
AU - Asakura, Kouichi
AU - Banno, Taisuke
N1 - Funding Information:
Dr. Keiichi Nakamoto (WITec K.K.) is acknowledged for the assistance of confocal Raman microscopy. This work was supported by Iketani Science and Technology Foundation and JSPS KAKENHI Grant Number 18K05066 for T.B.
Publisher Copyright:
© 2019 American Chemical Society.
PY - 2019/12/31
Y1 - 2019/12/31
N2 - Various amphiphiles including surfactants and lipids have been designed and synthesized to improve and create new functionalities. In particular, the emergence of cell-like behaviors of giant vesicles (GVs) composed of synthetic lipids has drawn much attention in the development of chemical models for cells. The aim of this study was to measure temperature-dependent morphological changes of GVs induced by fragmentation and subsequent growth using hydrolysable cationic lipids having an amide linkage. Results from differential scanning calorimetry, fluorescence spectroscopy using an environment-responsive probe, and confocal Raman microscopy showed that the dynamics observed were due to changes in the vesicle membrane, including variation in the lipid composition, induced by thermal stimulation.
AB - Various amphiphiles including surfactants and lipids have been designed and synthesized to improve and create new functionalities. In particular, the emergence of cell-like behaviors of giant vesicles (GVs) composed of synthetic lipids has drawn much attention in the development of chemical models for cells. The aim of this study was to measure temperature-dependent morphological changes of GVs induced by fragmentation and subsequent growth using hydrolysable cationic lipids having an amide linkage. Results from differential scanning calorimetry, fluorescence spectroscopy using an environment-responsive probe, and confocal Raman microscopy showed that the dynamics observed were due to changes in the vesicle membrane, including variation in the lipid composition, induced by thermal stimulation.
UR - http://www.scopus.com/inward/record.url?scp=85076969257&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85076969257&partnerID=8YFLogxK
U2 - 10.1021/acs.langmuir.9b02707
DO - 10.1021/acs.langmuir.9b02707
M3 - Article
C2 - 31797676
AN - SCOPUS:85076969257
VL - 35
SP - 17075
EP - 17081
JO - Langmuir
JF - Langmuir
SN - 0743-7463
IS - 52
ER -