Temporal trends in tolvaptan use after revision of national heart failure guidelines in Japan

Yusuke Yamazaki, Yasuyuki Shiraishi, Shun Kohsaka, Yuji Nagatomo, Keiichi Fukuda, Takashi Kohno, Tsutomu Yoshikawa

研究成果: Article査読

抄録

Within no definite diuretic protocol for acute heart failure (AHF) patients and its variation in regional clinical guidelines, the latest national guidelines in Japan commends use of tolvaptan in diuretic-resistant patients. This study aimed to examine trends in tolvaptan usage and associated outcomes of AHF patients requiring hospitalization. Between April, 2018 and October, 2019, 1343 consecutive AHF patients (median 78 [69–85] year-old) were enrolled in a prospective, multicenter registry in Japan. Trends over time in tolvaptan usage, along with the severity of heart failure status based on the Get With The Guideline-Heart Failure [GWTG-HF] risk score, and in-hospital outcomes were investigated. During the study period, tolvaptan usage has increased from 13.0 to 28.7% over time (p for trend = 0.07), and 49.4% started tolvaptan within 3 days after admission. The GWTG-HF risk score in the tolvaptan group has significantly decreased over time, while that in the non-tolvaptan group has unchanged. There were no differences in the in-hospital mortality rate between the patients with and without tolvaptan (6.7% vs. 5.8%). After revision of the Japanese clinical practice guidelines for AHF in March 2018, tolvaptan usage for AHF patients has steadily increased. However, in-hospital outcomes including mortality do not seem to be affected.

本文言語English
論文番号19360
ジャーナルScientific reports
11
1
DOI
出版ステータスPublished - 2021 12月

ASJC Scopus subject areas

  • 一般

フィンガープリント

「Temporal trends in tolvaptan use after revision of national heart failure guidelines in Japan」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル