Teriparatide therapy for bisphosphonate-associated osteonecrosis of the jaw in an elderly japanese woman with severe osteoporosis

Jun Iwamoto, Kaori Yago, Yoshihiro Sato, Hideo Matsumoto

研究成果: Article

17 引用 (Scopus)

抜粋

We report on the case of a severely osteoporotic elderly Japanese woman with bisphosphonate-associated osteonecrosis of the jaw (ONJ), who was treated successfully with teriparatide. A 79-year-old woman with severe osteoporosis and bisphosphonate-associated ONJ was treated with teriparatide after debridement of the necrotic tissue in the jaw bone. Computed tomography (CT) images revealed the bone defect in the mandible after debridement of the necrotic tissue associated with ONJ. According to the attending dentist, the ONJ healed after 2 months of therapy. After 3 months of treatment, a robust increase in the serum level of the bone formation marker, serum intact procollagen type 1 N-terminal propeptide, was noted and a repeat CT revealed improvement of the bone defect of the mandible. These results suggest the beneficial effects of teriparatide therapy in the severely osteoporotic elderly woman with ONJ.

元の言語English
ページ(範囲)547-553
ページ数7
ジャーナルClinical Drug Investigation
32
発行部数8
DOI
出版物ステータスPublished - 2012 7 12

ASJC Scopus subject areas

  • Pharmacology (medical)

フィンガープリント Teriparatide therapy for bisphosphonate-associated osteonecrosis of the jaw in an elderly japanese woman with severe osteoporosis' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用